Inline and Sideline Approaches for Low-cost Memory Safety in C

System languages such as C or C++ are widely used for their high performance, however the allowance of arbitrary pointer arithmetic and type cast introduces a risk of memory corruptions. These memory errors cause unexpected termination of programs, or even worse, attackers can exploit them to alter the behavior of programs or leak crucial data. Despite advances in memory safety solutions, high and unpredictable overhead remains a major challenge. Accepting that it is extremely difficult to achieve complete memory safety with the performance level suitable for production deployment, researchers attempt to strike a balance between performance, detection coverage, interoperability, precision, and detection timing. Some properties are much more desirable, e.g. the interoperability with pre-compiled libraries. Comparatively less critical properties are sacrificed for performance, for example, tolerating longer detection delay or narrowing down detection coverage by performing approximate or probabilistic checking or detecting only certain errors. Modern solutions compete for performance. The performance matrix of memory safety solutions have two major assessment criteria – run-time and memory overheads. Researchers trade-off and balance performance metrics depending on its purpose or placement. Many of them tolerate the increase in memory use for better speed, since memory safety enforcement is more desirable for troubleshooting or testing during development, where a memory resource is not the main issue. Run-time overhead, considered more critical, is impacted by cache misses, dynamic instructions, DRAM row activations, branch predictions and other factors. This research proposes, implements, and evaluates MIU: Memory Integrity Utilities containing three solutions – MemPatrol, FRAMER and spaceMiu. MIU suggests new techniques for practical deployment of memory safety by exploiting free resources with the following focuses: (1) achieving memory safety with overhead < 1% by using concurrency and trading off prompt detection and coverage; but yet providing eventual detection by a monitor isolation design of an in-register monitor process and the use of AES instructions (2) complete memory safety with near-zero false negatives focusing on eliminating overhead, that hardware support cannot resolve, by using a new tagged-pointer representation utilising the top unused bits of a pointer.Research Foundation of Kore

FRAMER: a tagged-pointer capability system with memory safety applications

Security mechanisms for systems programming languages, such as fine-grained memory protection for C/C++, authorize operations at runtime using access rights associated with objects and pointers. The cost of such fine-grained capability-based security models is dominated by metadata updates and lookups, making efficient metadata management the key for minimizing performance impact. Existing approaches reduce metadata management overheads by sacrificing precision, breaking binary compatibility by changing object memory layout, or wasting space with excessive alignment or large shadow memory spaces. We propose FRAMER, a capability framework with object granu- larity. Its sound and deterministic per-object metadata management mechanism enables direct access to metadata by calculating their location from a tagged pointer to the object and a compact sup- plementary table. This may improve the performance of memory safety, type safety, thread safety and garbage collection, or any so- lution that needs to map pointers to metadata. FRAMER improves over previous solutions by simultaneously (1) providing a novel encoding that derives the location of per-object metadata with low memory overhead and without any assumption of objects’ align- ment or size, (2) offering flexibility in metadata placement and size, (3) saving space by removing any padding or re-alignment, and (4) avoiding internal object memory layout changes. We evaluate FRAMER with a use case on memory safety

Influence of Oryzanol and Ferulic Acid on the Lipid Metabolism and Antioxidative Status in High Fat-Fed Mice

The comparative effects of oryzanol and ferulic acid on the lipid metabolism and antioxidative status of high fat-fed mice were investigated. The mice were given a diet containing 17% fat (HF), supplemented with oryzanol (HF-O) or ferulic acid for 7 weeks. The control mice (NC) were fed with normal diet. The HF mice exhibited increased body weight gain, plasma and hepatic total cholesterol and triglyceride concentrations, and lipid peroxidation rate, and reduced high-density lipoprotein cholesterol level. In general, they also showed lower hepatic antioxidant and higher lipid-regulating enzymes activities relative to that of NC group. Addition of oryzanol or ferulic acid in the diet counteracted these high fat-induced hyperlipidemia and oxidative stress via increased faecal lipid excretion and regulation of antioxidant and lipogenic enzymes activities. This study illustrates that oryzanol and ferulic acid have relatively similar hypolipidemic actions and could be effective in lowering the risk of high fat diet-induced obesity

Effect of freshwater discharge from Namgang Dam on ichthyoplankton assemblage structure in Jinju Bay, Korea

The movement of fish eggs and larvae in bay and estuarine systems is affected by freshwater discharge. In this study, the assemblage structures of ichthyoplankton eggs and larvae were assessed for the first time in Jinju Bay, South Korea, to identify the spawning and nursery functions of the bay. Fish eggs and larvae and several environmental parameters were sampled monthly from April 2015 to March 2016 inside and outside of the bay. Within the bay we collected eggs and larvae from 25 and 35 species, respectively, indicating greater diversity than outside the bay, where we collected eggs and larvae of 20 and 28 species, respectively. Fluctuations in water temperature and salinity were larger inside than outside of the bay, and chlorophyll-a concentration was higher within the bay, likely due to discharge from the Namgang Dam, which causes water to flow from the inside to the outside of the bay. This process influences fish larva abundance, such that more larvae are found outside than inside the bay. We also found that 28 fish species use Jinju Bay as a spawning ground. For some species, the timing of egg and larva appearance differed inside and outside of the bay, suggesting that the timing of spawning may differ between the two environments

Fabrication of pyramidal probes with various periodic patterns and a single nanopore

The nanometer-scale patterned pyramidal probe with an electron beam-induced nanopore on the pyramid apex is an excellent candidate for an optical biosensor. The nanoapertures surrounded with various periodic groove patterns on the pyramid sides were fabricated using a focused ion beam technique, where the optical characteristics of the fabricated apertures with rectangular, circular, and elliptical groove patterns were investigated. The elliptical groove patterns on the pyramid were designed to maintain an identical distance between the grooves and the apex for the surface waves and, among the three patterns, the authors observed the highest optical transmission from the elliptically patterned pyramidal probe. A 103-fold increase of the transmitted optical intensity was observed after patterning with elliptical grooves, even without an aperture on the pyramid apex. The nanopore on the apex of the pyramid was fabricated using electron beam irradiation and was optically characterized

Impact of national policy on hand hygiene promotion activities in hospitals in Korea

Background After the Middle East respiratory syndrome coronavirus outbreak in Korea in 2015, the Government established a strategy for infection prevention to encourage infection control activities in hospitals. The new policy was announced in December 2015 and implemented in September 2016. The aim of this study is to evaluate how infection control activities improved within Korean hospitals after the change in government policy. Methods Three cross-sectional surveys using the WHO Hand Hygiene Self-Assessment Framework (HHSAF) were conducted in 2013, 2015, and 2017. Using a multivariable linear regression model, we analyzed the change in total HHSAF score according to survey year. Results A total of 32 hospitals participated in the survey in 2013, 52 in 2015, and 101 in 2017. The number of inpatient beds per infection control professionals decreased from 324 in 2013 to 303 in 2015 and 179 in 2017. Most hospitals were at intermediate or advanced levels of progress (90.6% in 2013, 86.6% in 2015, and 94.1% in 2017). In the multivariable linear regression model, total HHSAF score was significantly associated with hospital teaching status (β coefficient of major teaching hospital, 52.6; 95% confidence interval [CI], 8.9 to 96.4; P = 0.018), beds size (β coefficient of 100 beds increase, 5.1; 95% CI, 0.3 to 9.8; P = 0.038), and survey time (β coefficient of 2017 survey, 45.1; 95% CI, 19.3 to 70.9; P = 0.001). Conclusions After the new national policy was implemented, the number of infection control professionals increased, and hand hygiene promotion activities were strengthened across Korean hospitals.This work supported by grants (2017 N-E2805–00) from Korea Centers for Disease Control, which had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript

Patterns of Recurrence after Breast-Conserving Treatment for Early Stage Breast Cancer by Molecular Subtype

Purpose: To study clinical features and patterns of recurrence after breast-conserving treatment (BCT) for three molecular subtypes of early stage breast cancer. Methods: The sample studied included 596 patients with T1-2N0-1 breast cancer who received BCT. Three groups were defined by receptor status. Luminal: estrogen receptor (ER) or progesterone receptor (PR) positive; triple negative (TN): ER, PR, and epidermal growth factor receptor-2 (HER2) receptor negative; and HER2 overexpressing: ER and PR negative but HER2 receptor positive. Results: The number of patients in each group was 408 (68.5%), 105 (17.6%), and 83 (13.9%), respectively. The median follow-up period was 79 months. The TN and HER2 subtypes occurred in younger patients (p=0.0007) and had higher nuclear grade and poorer histologic grade (p&lt;0.0001 and 0.0071, respectively). During the follow-up period, locoregional recurrence was detected as th